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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2013 Feb 18;6(2):392–401. doi: 10.1161/CIRCEP.111.000206

Figure 7. MOG1 rescued PM expression and function of Nav1.5/D1275N mutant.

Figure 7

A. WB analysis of Nav1.5 on the PM from tsA201 cells co-transfected with the wild-type (WT) or mutant (D1275N) SCN5A gene with (+) or without (−) MOG1. N-cadherin, loading control. B. Raw traces of a family of INa in cells transfected with WT (Top) or mutant (Bottom) SCN5A expression constructs without (−) or with (+) MOG1. C. Effects of MOG1 on the current-voltage relationship of WT and mutant Nav1.5. The current amplitudes were normalized to cell capacitance (pA/pF, abscissa). D. Effects of MOG1 on steady-state activation of WT and mutant Nav1.5. E. Effects of MOG1 on steady-state inactivation of WT and mutant Nav1.5. F. Effects of MOG1 on recovery from inactivation of WT and mutant Nav1.5.