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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2013 Feb 18;6(2):392–401. doi: 10.1161/CIRCEP.111.000206

Figure 8. Effects of MOG1 on PM expression and function of mutant Nav1.5/G1743R in the presence/absence of wild-type Nav1.5.

Figure 8

A. WB analysis of PM Nav1.5 level for WT or mutant (G1743R) channels with (+) or without (−) MOG1. N-cadherin, loading control. B. Raw traces of INa in cells transfected with WT SCN5A (Top), mutant SCN5A (G1743R, Middle) or an equal amount of mutant+WT (Bottom) without (−) or with (+) MOG1. C. Effects of MOG1 on the current-voltage relationship. D. Effects of MOG1 on steady-state activation. E. Effects of MOG1 on steady-state inactivation. F. Effects of MOG1 on recovery from inactivation.