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Schematic diagram illustrating the mechanisms underlying the GLT1 dysregulation in fmr1−/− astrocytes (A) FMRP-mediated translational regulation of mGluR5 contributes to neuron-dependent GLT1 expression in fmr1+/+ astrocytes. (B) Translational down-regulation of mGluR5, as a result of the loss of astroglial FMRP, underlies GLT1 dysregulation in fmr1−/− astrocytes.
