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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Neuron. 2011 Sep 21;71(6):1030–1042. doi: 10.1016/j.neuron.2011.07.021

Figure 5.

Figure 5

WGCNA analysis on the postmortem brain dataset. A. Dendrogram showing relationship of topological overlap of genes and their relation to modules. B. First module eigengene is plotted of the blue module, a measure of the general expression of the genes in a given module. Green samples are controls, red samples are FTD with GRN mutations, and blue samples are sporadic FTD. The module containing GRN, the blue module, is positively correlated with diseased GRN+ samples. This provides further evidence that GRN+ FTD has a distinct molecular phenotype even in late-stage FTD as compared to sporadic FTD. C. A graphic depiction of the blue module using VisANT (http://visant.bu.edu). For ease of viewing, pairs of genes with the highest intramodular topological overlap are depicted, with each link corresponding to a TO value between the connected nodes. This module is notable because it contains GRN. Its hub genes are ANXA5 and LRP10, indicating that this module is likely related to apoptosis and Wnt signaling. See also figure S7 and tables S5 and S6.