Table 3.
List of overrepresented motifs in the promoters of HG-upregulated genes
| TF Matrix | Gene | Enrichment Ratio | P Value |
|---|---|---|---|
| V$IRF_Q6 | IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8, IRF9 | 6.1891 | 3.92E-21 |
| V$IRF2_01 | IRF1, IRF2 | 4.5087 | 7.36E-15 |
| V$ISRE_01 | IRF7, IRF8, IRF9, STAT1, STAT2 | 3.1134 | 8.22E-13 |
| V$LRF_Q2 | ZBTB7A | 1.3964 | 4.50E-14 |
| V$VDR_Q3 | VDR | 1.2975 | 7.32E-21 |
| V$MAZ_Q6 | MAZ | 1.2861 | 1.50E-09 |
Each motif represents the corresponding transcription factor(s) listed in the “Gene” column. Enrichment ratio for each matrix represents the ratio of the average number of matched motif binding sites per 1,000 bp in the promoters of HG-upregulated genes vs. background genes (see materials and methods for background gene set selection). “TF Matrix”column shows the names of Transfac Position Weight Matrices (PWM) motifs. Significance of the representation is measured by the P value derived from binomial distribution. Motifs with P < 1×10−5 and enrichment ratio >1.25 are listed. The motifs in boldface (in the top 3 rows) are considered as highly enriched with P < 1E-12 and enrichment ratio > 3.