Table 5.

Expression levels of common genes present in both HGIN and IDIN gene sets in THP1 cells

Symbol	CpG Content	Representative Accession #	HG, RPKM	NG, RPKM	Fold Change
EPSTI1	HCP	NM_001002264	16.05	2.40	6.69
IRF7	HCP	NM_004029	47.21	4.90	9.63
EIF2AK2	HCP	NM_001135651	20.14	6.45	3.12
MX1	HCP	NM_002462	73.22	9.75	7.51
PLSCR1	HCP	NM_021105	51.88	18.30	2.84
WARS	HCP	NM_173701	179.09	49.38	3.63
ADAR	HCP	NM_015841	150.15	62.64	2.40
HAX1	HCP	NM_001018837	194.39	88.09	2.21
PARP12	ICP	NM_022750	16.77	4.21	3.99
PARP9	ICP	NM_001146105	15.96	4.92	3.24
MOV10	ICP	NM_001130079	31.88	12.23	2.61
ISG15	ICP	NM_005101	277.21	16.04	17.28
IFITM3	ICP	NM_021034	333.06	126.32	2.64
IFI44L	LCP	NM_006820	46.07	0.91	50.59
IFIT2	LCP	NM_001547	10.33	1.73	5.96
OASL	LCP	NM_003733	11.93	2.13	5.61
IFI44	LCP	NM_006417	68.89	2.73	25.23
IFI27	LCP	NM_005532	70.44	2.95	23.84
IFIT1	LCP	NM_001548	25.50	3.13	8.15
IFIT3	LCP	NM_001549	34.20	4.00	8.55
PARP10	LCP	NM_032789	42.14	6.03	6.99
SP110	LCP	NM_001185015	23.40	6.46	3.62
OAS1	LCP	NM_002534	76.30	8.70	8.77
OAS2	LCP	NM_001032731	59.23	9.58	6.19
IFI35	LCP	NM_005533	54.55	11.43	4.77
XAF1	LCP	NM_017523	37.42	11.74	3.19
IFI6	LCP	NM_022872	401.23	56.91	7.05
IFITM1	LCP	NM_003641	279.64	59.18	4.73

Twenty-eight genes shared in both high glucose-induced IRF network (HGIN) and IRF7-driven inflammatory network (IDIN) were obtained by comparing our HGIN with the published IDIN. These genes were further classified into high CpG content promoters (HCP), intermediate CpG content promoters (ICP), and low CpG content promoters (LCP) based on promoter CpG content (see materials and methods for classification criteria). For genes with multiple transcripts, 1 transcript was randomly chosen whose accession number is listed in the “Representative Accession #” column for each gene. The expression levels of the 28 genes and fold increase in HG are also shown.