Table 3.
Baseline |
Preischemic Treatment |
Ischemia |
Reperfusion |
|||||
---|---|---|---|---|---|---|---|---|
Control | GIK | Control | GIK | Control | GIK | Control | GIK | |
Anterior LV | ||||||||
Preload | ||||||||
Steady-state end-diastolic crystal area | 1 | 1 | 1.00±0.01 | 1.00±0.01 | 1.17±0.03* | 1.13±0.02* | 1.09±0.05 | 1.10±0.04* |
Systolic function | ||||||||
Steady-state external work | 1 | 1 | 0.97±0.03 | 0.95±0.03 | 0.21±0.05* | 0.32±0.04* | 0.18±0.06* | 0.38±0.05*† |
Fractional systolic wall area reduction | 0.28±0.02 | 0.29±0.02 | 0.28±0.02 | 0.29±0.02 | −0.02±0.02* | 0.08±0.01*‡ | 0.01±0.02* | 0.11±0.01*‡ |
Diastolic function | ||||||||
dA/dtmax | 1 | 1 | 0.99±0.04 | 1.01±0.06 | 0.62±0.04* | 0.92±0.11† | 0.52±0.07* | 0.77±0.05*† |
Posterior LV | ||||||||
Preload | ||||||||
Steady-state end-diastolic crystal area | 1 | 1 | 0.97±0.02 | 1.00±0.01 | 1.04±0.02 | 1.09±0.03* | 1.02±0.02 | 1.07±0.03* |
Systolic function | ||||||||
Steady-state external work | 1 | 1 | 0.99±0.04 | 0.99±0.02 | 0.93±0.04 | 0.95±0.05 | 0.83±0.02* | 0.87±0.07 |
Fractional systolic wall area reduction | 0.27±0.03 | 0.29±0.02 | 0.26±0.03 | 0.28±0.02 | 0.32±0.03* | 0.34±0.01* | 0.29±0.06 | 0.31±0.01 |
Diastolic function | ||||||||
dA/dtmax | 1 | 1 | 0.94±0.04 | 0.98±0.03 | 0.90±0.09 | 0.90±0.08 | 0.90±0.10 | 0.90±0.09 |
Values are means ± SE; n = 8 in each group. dA/dtmax, maximum rate of diastolic wall area expansion with respect to time. Except for fractional systolic wall area reduction, all values are expressed as fraction of baseline.
P < 0.05 vs. baseline within same group.
P < 0.05 and
P < 0.01 vs. control group under same condition.