Table 1.
Immune Function Genes With Significantly Induced Expression in Lung Granulomas Isolated From Sham-Vaccinated Nonhuman Primates Relative to Normal Nongranulomatous Tissue at 5 and 10 Weeks After Infection
| Category | Sham-Vaccinated/Mycobacterium tuberculosis (Week 5) | Sham-Vaccinated/Mycobacterium tuberculosis (Week 9) |
|---|---|---|
| Interferon | INDO (121.7), STAT1 (12.8), TAP1 (10.6), GBP1 (10.4), IFI30 (9.8), IRF1 (6.5), PSMB8 (4.7), IFN-γR2 (4.3), IFN-γ (3.8), IRF8 (3.2) | INDO (25.5), IFN-γ (11.5), GBP1 (11), STAT1 (7.1) |
| Tumor necrosis factor | TNFSF13B (10.3), LITAF (7.6), LTB (3.8), TNIP2 (3.1) | TNFSF13B (5.4), LITAF (3.5), LTA (3.1) |
| Chemokine | CXCL6 (21.8), CXCL1 (19.7), CXCL3 (14.5), CXCL10 (10.9),CXCL9 (9.6), CCL2 (8.3), CXCL14 (4.2), CCL19 (3.9), CCL11 (3.5) | CXCL11 (29), CXCL1 (26.5), CXCL10 (14.5),CXCL13 (10), CXCL3 (9.7), CXCL9 (7.1),CXCL16 (4.7), CCL19 (4.3) |
| Proinflammatory cytokines | IL1B (12.8), IL6 (12.1), IL1RN (3.4) | |
| Anti-inflammatory cytokines | IL4R (4.9), IL10 (3.4), IL10RA (3.4) | IL10RB (6.1), IL10 (4.7) |
| Innate immunity | C1QA (16.6), APOL1 (13.3), KYNU (10.8), APOBEC3G (9.2),TLR2 (9.0), CYBB (8.9), IER3 (8.6), C3 (7.2), C1S (6.8),GCH1 (5.9), ITGAM (5.8), SERPING1 (5.2), C1QBP (4.1),C1QB (4.1), C2 (3.6), TLR8 (3.4), NCF2 (3.2) | TLR2 (8.3), CYBB (7.8), TLR8 (4.5), ITGAM (9.5),CR2 (8.7), C1QA (4.7), APOL1 (4.1), IER3 (3.1),NCF2 (3) |
| Defense response | LYZ (85.3), TFRC (16), HLA-DRA (14.8), RNASE3 (11.2),CD74 (11), TAP1 (10.6), LY96 (10), CD14 (9.1), TF (8.1), PSG4 (8),ITGB2 (7.3), B4GALT1 (6.7), VSIG4 (6.6), CLIC1 (6.5),HIST1H2BK (6.4), CD48 (6.3), FGR (6.2), SERPINA1 (5.9),FN1 (5.7), TAPBP (5.1), NMI (4.8), SELS (4.6), CD44 (4.6),PLA2G4C (4.6), COTL1 (4.5), LYN (4.2), CD97 (3.9), CD83 (3.6),ITGB1 (3.6) S100A8 (3.5), CEBPB (3.4), SPP1 (3.3),VDAC3 (3.3), TYROBP (3.1), AOAH (3.1), VDAC1 (3.1) | PLA2G7 (11.3), VSIG4 (6.4), LY86 (6.1), RNASE3 (5.6), LY96 (5.1), AOAH (5.1), SLAMF8 (4.5), CD83 (4.3),HMOX1 (4.0), CD74 (3.3.), LY75 (3.2) |
| Apoptosis | CTSB (42.5), CD74 (11), MMP9 (8.8), CASP4 (8.2), SEMA4D (6),BIRC3 (5.6), TPT1 (5.3), UBB (4.9), LGALS1 (4.7), CD44 (4.6),CASP1 (4.5), ANXA4 (4.4), GFBP3 (4.4), BTG1 (4.1), HBXIP (4.1),CYCS (4), RPL11 (3.9), GPR109A (3.8), SOD2 (3.8), CASP3 (3.7),CD2 (3.6), CEBPB (3.4), RPS27A (3.3), NME2 (3.3), NPM1 (3.2),CFL1 (3.2), PYCARD (3.1), MCL1 (3.1), PDCD5 (3.1), RPS6 (3.1) | SOD2 (32.2), MMP9 (25.7), BCL11B (7.9), CTSB (7.9),JAK2 (7.6), VDR (7), CHST11 (6.2), BIRC3 (5.1),KCNMA1 (5.1), CDH1 (4.3), PPT1 (4.1), BCL10 (3.9),CALR (3.8), SEMA4D (3.5), CASP4 (3.4), ACTN1 (3),CARD14 (3), CDKN1B (3), MAP3K5 (3),ANXA4 (3) |
Official National Center for Biotechnology Information human gene symbols are used to denote genes. Numbers in parentheses signify the numeric fold-change of expression for that gene. Functional groupings were constructed using DAVID (http://david.abcc.ncifcrf.gov/). Genes in boldface were present in the data set at both time points.