Table 2.
Immune Function Genes With Significantly Induced Expression in Lung Granulomas Isolated From BCG-Vaccinated Nonhuman Primates Relative to Normal Nongranulomatous Tissue at 5 and 10 Weeks After Infection
| Category | BCG-Vaccinated/Mycobacteriumtuberculosis (Week 5) | BCG-Vaccinated/Mycobacteriumtuberculosis (Week 9) |
|---|---|---|
| Interferon | IFN-γ (30.2), INDO (22.6), GBP1 (17.3), GBP2 (7.1), IRF1 (6.1), IFRG28 (5.2), IFI30, STAT1 (5.1), FASLG (4.9), IL18 (4.7),IRF7 (4.2), IRF8 (3.8), ISG20 (3.5), STAT5A (3) | INDO (7.8), STAT1 (5.9) |
| Tumor necrosis factor | LTB (9.8), TNFSF13B (8.6), TNFRSF11B, TNIP3 (7),C1QTNF (6.8), TNFAIP6 (6.5), TNFAIP3 (6), TNFRSF21 (5.9),TRAF3 (5.6), LTA (5.3), TNFAIP8 (3.5), TNFSF5 (3.2), TNIP2,TNF (3) | TNFSF13B (5.3), LITAF (3.6), C1QTNF, LTB (3) |
| Chemokine | CXCL6 (57.3), CXCL9 (47.1), CCL2 (38.2), CXCL11 (38.2),CXCL10 (37.4), CXCL1 (31.8), CXCL3 (18.2), CCL19 (11.2),CXCL13 (9.8), CCR1 (8.2), CXCL12 (7.6), CXCL14 (7.5),CXCR4 (7.2), CCR5 (5.8), CXCL2 (5.5), CCL11 (5.3), CCR2(4.1), CXCL16 (4), CCL13 (3.9), CCR7 (3.5), CCL20, CCL4 (3) | CXCL6 (11.1), CXCL13, CXCR4 (5.7), CCL2 (5.6),CCL19 (4) |
| Proinflammatory cytokines | IL6 (69.2), IL1R2 (12.5), IL1B (12.4), IL15RA (6.9), IL1RAP(6.1), IL18RAP (5.3), IL21R, IL18R1 (4.7), IL2RA (4.5),IL27RA (3.4), IL12RB2 (3.1) | |
| Anti-inflammatory cytokines | IL10 (13), IL4I1 (10), IL11 (7.8), IL4R (4.4), IL10RA (3.8),SOCS1 (3.6), IL10RB (3.5) | IL4R (4.5), IL10RA (4.4), IL13RA1 (3.3) |
| Innate immunity | VSIG5 (16.8), TLR4 (10.2), CR2 (9.1), IER3 (9), LAG3 (8.2), TLR2 (7.3), C4B (5.6), TLR8 (5.1), IRAK2 (4.2), C1S (4.5), C4BPA(3.8), C1QB (3.3), C1QA (3.2), MYD88 (3) | C3 (6.7), C1QA (5.6), C1S (5.7), C4B (5), IER3 (4.7),C4BPA (3), MYD88, NFKBIA (3) |
| Defense response | MMP1 (84.1), INHBA (47.3), SPP1 (37.9), SAA1 (36.7),SAA2 (34.3), S100A8 (33.2), SLAMF7 (29.1), HP (18.9),KYNU (16.5), SERPINA3 (15.3), SAA4 (14.9), ANKRD1 (13.3), GCH1 (10.1), CSF3R (9.7), TFRC (8.5), CYBB (8.3), LYZ (8.1), AOAH, GAL (7.8), IGFBP4, THBS1 (7.4), RNASE3,SERPINA1 (6.7), APOL2 (6.4), APOL1, SERPINF2 (5.7),LY86 (5.5), APOL3, ORM1 (5), PLA2G7, KCNN4 (4.9), LY96 (4.5), B4GALT1, TAP1 (4.4), PSG4 (4.3) RNASE6, PLA2G4C(4.2), HMOX, CD48 (4.1), PTX3, LYN, RIPK2 (4), CD44 (3.9), APOBEC3G (3.8), ADORA2B, PTAFR (3.7), CD83 (3.5), FGR(3.4), CYBA, CLIC1 (3.1), CLEC5A, CD40, NOX1, AIF1, SELS(3) | MMP1 (12.5), APOL1 (10.1), LYZ (8.8), CD74 (8.2),SPP1 (7.8), FN1 (7.6), B4GALT1 (7), TAP1 (6.1),HLA-DRA (6), SERPINA3 (4.7), CD48 (4.6), TFRC (4.3), CLIC1, COTL1 (4.1), CYBB (3.9), LYN (3.8),SERPINA1 (3.6), LY86 (3.5), SELS (3.4), LTA4H (3.3),CD83, PSG4 (3.2), BLNK, FGR, MNDA, NMI, VDAC3(3) |
| Apoptosis | SOD2 (29.7), BID (14.2), GPR109A (13.3), GREM1 (12.6),SFRP5 (9.5), GPR65 (8), EGLN3, THBS1 (7.5), SGTB (6.2),DDIT4 (6), STEAP3 (5.8), BIRC3, TWIST1 (5.7), ZC3H12A(5.5), PHLDA2 (5.1), FADD (4.9), FASLG (4.7), OSM (4.5),CASP4 (4.1), BCL2L14, SGPL1 (3.9), CYCS, JAK2 (3.4),BNIP2, CD14, GADD45A, ITGB2, SIAH2, UNC5B (3.2),ALDOC, NEK6, PYCARD (3) | PIM2 (8.1), CTNNB1 (6.5), SIAH2 (5.2), ITGB2, RASSF5 (4.6),BIRC3, MAGEH1 (3.8), POLR2G (3.5), CD14, PREX1,YWHAE (3.4), MCL1, RTN4 (3.3), CASP4 (3.2), YWHAB (3.1), MAP3K1 (3) |
Official National Center for Biotechnology Information human gene symbols are used to denote genes. Numbers in parentheses signify the numeric fold-change of expression for that gene. Functional groupings were constructed using DAVID (http://david.abcc.ncifcrf.gov/).