Taxol promotes tumor cell-ECM binding. Equivalent concentrations of MDA-436 cells were plated over gelatin-coated coverslips in serum-free media supplemented with 500nMjas (C and D), 1.17μMTaxol (E and F), jas + Taxol (G and H) or 125μM colchicine (I and J). After 45 minutes, unattached cells were removed by gentle aspiration and washing, and attached cells were fixed and labeled with a nuclear dye (A, C, E, G, I) and a fluorescent phalloidin conjugate (B, D, F, H, J). Images were captured at 10X magnification, revealing differences in total numbers of attached cells.