Table 3.
Multinomial logistic regression for the association (OR, 95%CI) between psychiatric disorders and DSM-IV cannabis abuse/dependence and three classesa of subjective effects to cannabis among 414 offspring who used cannabis at least once.
| Class 1 (high responder) vs. Class 3 (mixed/relaxed) |
Class 2 (positive responder) vs. Class 3 (mixed/relaxed) |
|
|---|---|---|
| Familial risk | ||
| 4-Group designb | ||
| Group 1 HG–HE | 0.91 (0.38–2.19) | 0.95 (0.42–2.17) |
| Group 2 HE–LE | 1.37 (0.43–4.41) | 1.84 (0.49–6.93) |
| Group 3 MG–LE | 0.73 (0.24–2.27) | 1.53 (0.55–4.28) |
| Group 4 LG–LE | 1.0 | 1.0 |
| Maternal cannabis abuse/dependence | 0.49 (0.18–1.32) | 0.94 (0.37–2.38) |
| Maternal data missing | 0.75 (0.36–1.53) | 1.21 (0.60–2.46) |
| Sociodemographics | ||
| Age | 0.96 (0.89–1.03) | 1.01 (0.95–1.09) |
| Male gender | 2.08 (1.24–3.48) | 2.03 (1.17–3.50) |
| White | 1.67 (0.82–3.40) | 0.83 (0.45–1.54) |
| Paternal household income | ||
| ≤20,000 | 1.80 (0.55–5.90) | 2.61 (0.81–8.36) |
| 20,001–100,000 | 1.0 | 1.0 |
| ≥100,000 | 0.91 (0.44–1.87) | 1.04(0.46–2.38) |
| Used illegal drugs other than cannabis | 1.04 (0.58–1.88) | 0.64 (0.34–1.18) |
| Cannabis use disorder | ||
| No diagnosis | 1.0 | 1.0 |
| Abuse | 2.05 (1.13–3.73)a | 1.03 (0.55–1.92)b |
| Dependence | 37.13 (4.60–299.78)a | 5.76 (0.63–52.43)b |
a and b—post hoc contrasts: within rows, odds ratios with ditterent letters (a and b) are significantly different, p < 0.01.
The significance is the OR and 95%CI. Readers will use the CI to interpret significance.
Class 1—high responder, Class 2—positive responders, Class 3—mixed/relaxed.
4-Group design: Group 1—offspring at highgenetic (HG) and high environmental (HE) risk because fathers are MZ and DZ twins with DSM-III-R illicit drug dependence: Group 2—offspring at high genetic (HG) and low environmental (LE) risk because fathers are unaffected MZ twins with DSM-III-R illicit drug dependent co-twins: Group 3—offspring at medium genetic (MG) and LE risk because fathers are unaffected DZ with DSM-III-R illicit drug dependent co-twins: Group 4—offspring at low genetic and LE because fathers are unaffected MZ and DZ control pairs.