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. Author manuscript; available in PMC: 2014 Mar 20.
Published in final edited form as: Bioconjug Chem. 2013 Feb 14;24(3):473–486. doi: 10.1021/bc300610f

Table 2.

MIC values (µM) of compounds 1b–3b and 1c–3c against S. aureus SG511 under varying concentrations of Fe(III).a.b

Test Organism
Staphylococcus aureus SG511
Entry Compound MHII + Feb MHII − Fec
1 1b 16 16
2 2b 128 64
3 3b 128 64
4 1c 64 32
5 2c 64 64
6 3c 4 1
8 Lorabid® 1 1
9 ciprofloxacin 0.5 0.5
a

MIC values were determined using the broth microdilution method using visual end point analysis according to the CLSI guidelines.(40)

b

Each compound was tested in triplicate.

c

MHII + Fe: Mueller-Hinton Broth No. 2 + 100 µM FeCl3.

d

MHII − Fe: Mueller-Hinton Broth No. 2 + 100 µM 2,2’-bipyridine.