Figure 4. 1.

Neuroblastoma localization. Neuroblastoma primary tumors derive from precursor cells of the peripheral (sympathetic) nervous system and can arise anywhere along the sympathetic chain, most frequently in the adrenal gland (position 8 as shown). Neuroblastoma may also develop from spinal cord of neck (position 6) and pelvis (position 10). Neuroblastomas mainly metastasize to lymph nodes (position 3), liver (position 4), bone and bone marrow (position 5), and also spread to central nervous system (position 1) and lungs (position 2) in infants.