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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: Curr Top Dev Biol. 2011;94:77–127. doi: 10.1016/B978-0-12-380916-2.00004-8

Table 4. 1.

Neuroblastoma risk stratification based on age, MYCN status and histology

INSS stage Age MYCN status Histology Risk group 3-year survival rate
1 0–21 years Any Any Low >90%
2 0–21 years Non-Amp Any Low 70–90% in this stage
1–21 years Amp Favorable Low
1–21 years Amp Unfavorable High
3 <1 year Non-Amp Any Intermediate 30–50% in this stage
1–21 years Non-Amp Favorable Intermediate
0–21 years Amp Any High
0–21 years Non-Amp Unfavorable High
4 <1 year Non-Amp Any Intermediate <30% in this stage
0–21 years Amp Any High
4S <1 year Non-Amp Favorable Low 50–80% in this stage
<1 year Non-Amp Unfavorable Intermediate
<1 year Amp Any High

INSS, International Neuroblastoma Staging System; Amp, amplified; Non-Amp, not amplified.