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. Author manuscript; available in PMC: 2013 Apr 23.
Published in final edited form as: J Immunol. 2008 May 1;180(9):6159–6167. doi: 10.4049/jimmunol.180.9.6159

Figure 1.

Figure 1

Prime boost schedule for the heterologous vaccine protocol. Naïve mice are immunized with 2 doses of HBsAg-DNA delivered intramuscularly (i.m.; 10–100μg/dose) followed by one dose of HBsAg-liposomes delivered intranasally (i.n.; 3 or 15 μg/dose). DNA immunizations may be delivered in 3 weeks (long protocol) or 3 days (short protocol). Liposomes are delivered 2–4 weeks after the last DNA immunization. Maximal immune responses are detected beginning two weeks following the final immunization.