Figure 5.
Short (3 days) and long (3 weeks) DNA priming regimens are both effective at priming for antibody responses. Groups of female Balb/c mice were immunized with 50μg of HBsAg-DNA i.m. on days 0 and 2 (short protocol) or 100μg of HBsAg-DNA i.m. on day 0 and week 3 (long protocol) followed by 15μg of HBsAg-liposomes i.n. 3 weeks after the last DNA immunization. Antibody responses were measured 2 weeks after the liposome immunization. Average HBsAg-specific IgG responses (μg/ml) +/− SEM are shown. From top to bottom, n= 8, 6, 8, and 12 per group.