Table 1.
Common susceptibility loci for prostate cancer identified through GWAS that was genotyped
| Locus | SNP | RAF* | Per allele OR (95% CI)* | Nearby genes | Reference |
|---|---|---|---|---|---|
| 2p11 | rs10187424 | 0.41 | 0.92 (0.89–0.94) | GGCX/VAMP8 | [14] |
| 2p15 | rs721048 | 0.19 | 1.15 (1.10–1.21) | Intronic in EHBP1 | [23] |
| 2p21 | rs1465618 | 0.23 | 1.08 (1.03–1.12) | Intronic in THADA | [24] |
| 2q31 | rs12621278 | 0.06 | 0.75 (0.70–0.80) | Intronic in ITGA6 | [24] |
| 2q37 | rs2292884 | 0.25 | 1.14 (1.09–1.19) | MLPH | [14] |
| 3p12 | rs2660753 | 0.11 | 1.18 (1.06–1.31) | [25] | |
| 3q21 | rs10934853 | 0.28 | 1.12 (1.08–1.16) | Intronic in EEFSEC | [26] |
| 3q23 | rs6763931 | 0.45 | 1.04 (1.01–1.07) | Intronic in ZBTB38 | [14] |
| 3q26 | rs10936632 | 0.48 | 0.90 (0.88–0.93) | CLDN11/SKIL | [14] |
| 4q22 | rs17021918 | 0.34 | 0.90 (0.87–0.93) | Intronic in PDLIM5 | [24] |
| 4q22 | rs12500426 | 0.46 | 1.08 (1.05–1.12) | Intronic in PDLIM5 | [24] |
| 4q24 | rs7679673 | 0.45 | 0.91 (0.88–0.94) | TET2 | [24] |
| 5p12 | rs2121875 | 0.34 | 1.05 (1.02–1.08) | Intronic in FGF10 | [14] |
| 5p15 | rs2242652 | 0.19 | 0.87 (0.84–0.90) | Intronic in TERT | [14] |
| 6p21 | rs130067 | 0.21 | 1.05 (1.02–1.09) | Missense coding in CCHCR1 | [14] |
| 6q25 | rs9364554 | 0.29 | 1.17 (1.08–1.26) | Intronic in SLC22A3 | [25] |
| 7p15 | rs10486567 | 0.77 | 0.74 (0.66–0.83) | Intronic in JAZF1 | [27] |
| 7q21 | rs6465657 | 0.46 | 1.12 (1.05–1.20) | Intronic in LMTK2 | [25] |
| 8p21 | rs2928679 | 0.42 | 1.05 (1.01–1.09) | SLC25A37 | [24] |
| 8p21 | rs1512268 | 0.45 | 1.18 (1.14–1.22) | NKX3.1 | [24] |
| 8q24 | rs1447295 | 0.11 | 1.62 | [28] | |
| 8q24 | rs6983267 | 0.50 | 1.26 (1.13–1.41) | [29] | |
| 8q24 | rs16901979 | 0.09 | 1.79 (1.36–2.34) | [30] | |
| 8q24 | rs10086908 | 0.30 | 0.87 (0.81–0.94) | [31] | |
| 8q24 | rs12543663 | 0.31 | 1.08 (1.00–1.16) | [31] | |
| 8q24 | rs620861 | 0.37 | 0.90 (0.84–0.96) | [31] | |
| 9q33 | rs1571801 | 0.25 | 1.27 (1.10–1.48) | Intronic in DAB21P | [32] |
| 10q11 | rs10993994 | 0.40 | 1.25 (1.17–1.34) | Promoter of MSMB | [25,27] |
| 10q26 | rs4962416 | 0.27 | 1.20 (1.07–1.34) | Intronic in CTBP2 | [27] |
| 11p15 | rs7127900 | 0.20 | 1.22 (1.17–1.27) | [24] | |
| 11q13 | rs7931342 | 0.49 | 0.84 (0.79–0.90) | [25, 27] | |
| 12q13 | rs10875943 | 0.31 | 1.07 (1.04–1.10) | TUBA1C/PRPH | [14] |
| 17q12 | rs4430796 | 0.49 | 1.22 (1.15–1.30) | Intronic in HNF1B | [33] |
| 17q12 | rs11649743 | 0.80 | 1.28 (1.07–1.52) | Intronic in HNF1B | [34] |
| 17q24 | rs1859962 | 0.46 | 1.20 (1.14–1.27) | [33] | |
| 19q13 | rs2735839 | 0.15 | 0.83 (0.75–0.91) | KLK2/KLK3 | [25] |
| 22q13 | rs5759167 | 0.47 | 0.86 (0.83–0.88) | BIL/TTLL1 | [24] |
| Xp11 | rs5945619 | 0.36 | 1.19 (1.07–1.31) | NUDT11 | [23, 25] |
| Xq12 | rs5919432 | 0.19 | 0.94 (0.89–0.98) | AR | [14] |
*
Data for RAF (risk allele frequency) and per allele OR (odds ratio) are taken from the original publications. 95% CIs are given in brackets where available.