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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Immunol. 2013 Mar 27;190(9):4685–4691. doi: 10.4049/jimmunol.1202672

Figure 1. The Role of Platelets in ECM is Time Dependent.

Figure 1

A. Platelets are activated early in ECM. Mice were infected with P. berghei and plasma PF4 concentration measured by ELISA (bars). The corresponding parasitemia (line) was also determined at the same time points. (N=5 per timepoint, mean ± SD,*P<0.05).

B. Platelet depletion pre-infection is not ECM protective. Mice were platelet depleted 24 hrs before or after P. berghei ANKA infection and survival monitored Mice depleted of platelets post infection, but not pre-infection had improved survival. (N=5,*P<0.05, log-rank test).

C. Platelet inhibition pre-infection is also not protective. Mice were treated with clopidogrel beginning 24 hours pre- or post P. berghei infection and survival monitored. (N=10,* P<0.05 log-rank test).

D. Mice platelet depleted pre-infection have in increased parasitemia. Mice were platelet depleted 24 hours prior to P. bergehi infection and the number of infected RBCs compared with non platelet-depleted controls was determined at day 5 (N=5, mean ± S.D, *P≤0.05).