Table 3.
Risk of Barrett's esophagus and daily intake of folate (151 cases and 777 controls)
| Food groups | Tertile 1 | Tertile 2 | Tertile 3 | P valuec |
|---|---|---|---|---|
| Folate from foods (μg) | ||||
| Median (Range) | 92.2 (<109) | 125 (109-141) | 168 (141-542) | |
| case/control | 59/259 | 49/259 | 43/259 | |
| ORa (95% CI) | 1.00 | 0.81(0.53-1.24) | 0.67 (0.43-1.05) | 0.08 |
| ORb (95% CI) | 1.00 | 0.85(0.51-1.41) | 0.58 (0.33-1.00) | 0.05 |
| Fortified folic acid (μg) | ||||
| Median (Range) | 37.3 (<48.6) | 58.9 (48.6-70.7) | 94.3 (70.7-588) | |
| case/control | 62/259 | 50/259 | 39/259 | |
| ORa (95% CI) | 1.00 | 0.81 (0.53-1.24) | 0.66 (0.42-1.03) | 0.07 |
| ORb (95% CI) | 1.00 | 0.75 (0.45-1.24) | 0.74 (0.43-1.28) | 0.25 |
| Folate acid supplement (μg) | ||||
| Dose | 0 | < 400 | ≥ 400 | |
| case/control | 69/383 | 12/77 | 70/317 | |
| ORa (95% CI) | 1.00 | 0.97 (0.50-1.90) | 1.24 (0.85-1.80) | 0.27 |
| ORb (95% CI) | 1.00 | 1.21 (0.56-2.59) | 1.19 (0.76-1.88) | 0.45 |
| Total folate (μg) | ||||
| Median (Range) | 179 (< 209) | 230 (209-260) | 316 (260-1123) | |
| case/control | 67/259 | 45/259 | 39/259 | |
| ORa (95% CI) | 1.00 | 0.68 (0.44-1.04) | 0.57 (0.36-0.88) | 0.01 |
| ORb (95% CI) | 1.00 | 0.59 (0.36-1.01) | 0.52 (0.30-0.67) | 0.02 |
a
OR was adjusted for age and energy intake.
b
OR was adjusted for age, energy intake, sex, ethnicity, smoking status, alcohol consumption, waist to hip ratio (tertile), ever or never use of aspirin, ever or never use of proton pump inhibitor, frequency of the GER symptoms, and physical activity (low, moderate, and high according to metabolic equivalent of task).
c
P value for trend across tertiles.