Table 1.
Heavy and light chain CDR3 sequences of vimentin-reactive FL Igs
| PtID # | Isotype | VH | D | JH | VH-CDR3 | VL | JL | VL-CDR3 |
|---|---|---|---|---|---|---|---|---|
| 259 | IgMκ | 3-11 | 2-21 | 3 | AKNRSHT VMVFNN ETRRNDA TRHDVFD I | Vκ1-33 | 2 | QQCDNF PYT |
| 195 | IgMκ | 3-23 | 5-12 | 6 | ATSRGYD NYMDV | Vκ3-20 | 1 | HQYGRS PQT |
| 185 | IgMλ | 3-33 | 3-10 | 3 | ARNATST SGTYSVG YAFDF | Vλ2-23 | 3 | CSYAGTS TLV |
| 212 | IgMκ | 3-48 | 2-21 | 5 | AKGSGLL SNAFDP | Vκ1-39 | 1 | QQSYSG PWT |
| 286 | IgMκ | 3-48 | 6-19 | 5 | ARVGGA VRHWFD P | Vκ3-11 | 3 | QQRTNW PPT |
| 186 | IgMκ | 3-7 | 3-10 | 4 | ARNRSEF DY | Vκ2-30 | 4 | MQGTHW PPFT |
| 314 | IgMκ | 4-34 | 2-2 | 4 | VRGEIVIV PASRRSY MDV | Vκ3-20 | 5 | QQYGNS YPVT |
| 209 | IgMκ | 4-39 | 4-17 | 4 | ARRPLNG VTTVTHE DY | Vκ3-11 | 4 | QQRSNW PLT |
| 305 | IgMk | 4-59 | 3-16 | 5 | ARDRGG DRFDH | Vκ4-1 | 1 | HQYYNSP AT |
| 310 | IgMλ | 4-59 | 5-24 | 6 | ARHREA NIQVTNT SPLSDG MDV | Vλ3-25 | 3 | QSADST GTCV |
| 337 | IgMλ | 4-59 | 6-19 | 3 | ARGAVAG SLDGFDV | Vλ2-14 | 3 | TSFTSST TLV |
| 224 | IgGk | 1-18 | 4-17 | 6 | ATADGAY NTMDV | Vκ1-5 | 5 | QSYKVY GVS |
| 231 | IgGk | 1-18 | 1-1 | 5 | VNASGTV GDWLDP | Vκ1-39 | 2 | QQTYSTL RET |
| 294 | IgGk | 1-18 | 2-21 | 6 | ARNSTSV SYSDTD WHGMDF | Vκ1-16 | 1 | QQYYVY PPT |
| 200 | IgGλ | 1-46 | 4 | 4 | ARDDYIK TRLYFLD S | Vλ1-47 | 3 | TTWDDSL PGYWV |
| 228 | IgGλ | 1-69 | 6-6 | 6 | ARGLFYS TSSRYYH YYAMDV | Vλ1-44 | 3 | AAWDDS LNGWV |
| 301 | IgGk | 1-8 | 6-19 | 4 | AVNYTSG SLDY | Vκ4-1 | 1 | QQYYNT PRT |
| 266 | IgGλ | 3-15 | 4-4 | 5 | VNSTNN WAGNNL VDP | Vλ1-44 | 7 | AAWDDS LSGLV |
| 13 | IgGλ | 3-21 | 6-6 | 6 | VRNSSSS AGSDYC GLDV | Vλ1-40 | 7 | QSYDSR VSGSVV |
| 313 | IgGλ | 3-21 | ARIAGGA TVLVHSY VMDV | Vλ2-18 | ALFTNNL KWV | |||
| 316 | IgGλ | 3-21 | 3-3 | 6 | TRDLRPS FWSAFQ RLAYYYG MDV | Vλ3-19 | 2 | NSRDTN DNHVL |
| 351 | igGk | 3-23 | 6-13 | 4 | SAAVGLP LET | Vκ3-20 | 1 | RQYGHS PQT |
| 15 | IgGk | 3-30 | 3-10 | 4 | AKPPTP WKGTNY YLDF | Vκ3-11 | 3 | QQRRV |
| 253 | IgGA | 3-30 | 1-1 | 3 | VNKTGTH GFDI | Vλ2-8 | 3 | SSYAGG DNFLWV |
| 211 | IgGk | 3-48 | 4-17 | 4 | ARVKKS WGRLGG LDL | Vκ1-39 | 1 | QQTYSG PQT |
| 384 | IgGk | 3-48 | 3-9 | 5 | ARTTACN TSDCSVK AFDC | Vκ3-15 | 2 | QQYSNW PPYT |
| 323 | IgGλ | 3-48 | 3-3 | 3 | VRNESW AFDM | Vλ2-11 | 3 | CSYAGSF TWV |
| 325 | IgGλ | 3-48 | 3-3 | 1 | ARHRVR SGNYAKT LEK | Vλ1-44 | 3 | AAWDDS LNGWV |
| 280 | IgGλ | 3-49 | 3-16 | 3 | ARSPQM NLLVDLPI IFGNNVL DL | Vλ1-40 | 2 | QSYDKTR RSLL |
| 339 | IgGk | 3-53 | 3-16 | 6 | ARESLAG EEIPNGM DV | Vκ4-1 | 2 | QQFYSSS RT |
| 189 | IgGλ | 3-53 | 4-23 | 6 | AIGTSTT VGGMDV | Vλ1-47 | 2 | AAWDDT LSGPV |
| 265 | IgGλ | 3-74 | 3-10 | 4 | TRNASGP LMDFDK | Vλ4-69 | 3 | QTWGTGI DWV |
| 25 | InGλ | 3-h | 1-26 | 5 | TRDLYNG AYTLHP | Vλ1-44 | 2 | ASWDDR LNGLL |
| 21 | IgGk | 4-34 | 1-7 | 6 | AEGGPK SYYGLDV | Vκ3-15 | 1 | QQSSHG PPKT |
| 245 | IgGk | 4-39 | 1-1 | 5 | ATNFSRN SNDKPFV Y | Vκ1-5 | 4 | QQYNFS ST |
| 299 | IgGk | 4-39 | 2-2 | 5 | VKRSTSG RNWFDP | Vκ1-39 | 4 | QQTYSIP LT |
| 285 | IgGλ | 4-39 | 4-17 | 6 | ARNMTLV TGGFYGL DV | Vλ1-47 | 3 | AIWDDRL SGWV |
| 317 | IgGλ | 4-39 | 2-2 | 4 | VRLNSTT FFDN | Vλ1-51 | 3 | GTWNSS LTGNTSL SVHWV |
| 303 | IgGλ | 4-59 | 3-10 | 4 | ARGPQIR LHFGESL LFDL | Vλ2-23 | 2 | CSYASSN TFI |
Pt 9,23, and 27: Data not available; Pt 23: polyreactive tumor Ig; Gray boxes: polyreactive tumor Igs