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Myelin protein levels were increased in BACE1-null mice with overexpression of Akt-DD transgene. Protein lysates were prepared from the indicated genotypes of mouse brains, and equal amounts of proteins were examined by Western blot analysis. Akt-DD transgene was detectable by antibody specific to Akt1. Protein level relative to the loading control actin was quantified and is presented as bar graphs (n=4 animals/group). *P < 0.01.
