Figure 5.

Hypomyelination in BACE1-null sciatic nerves was not affected by the overexpression of Akt-DD. Fixed sections of sciatic nerves from the indicated genotype of mice (2 mo old) were examined by electron microscopy. Hypomyelination is evident in the nerves of BACE1-null mice (top right image) compared with wild-type controls (top left image). Slightly thicker myelin sheaths were seen in BACE1^−/−/TgAktDD (bottom right image) and BACE1^+/+/TgAktDD (bottom left image) sciatic nerves. However, g ratios, calculated from the indicated genotype of sciatic nerves shown in the scatter plot (right panel), showed no significant reversion of hypomyelination (n=3 animals). Scale bars = 1 μm.