Figure 1. Illustrative biomarker time course following a cardiac arrest.

Baseline creatinine was 96 µmol/l. Horizontal dotted lines represent the thresholds for Functional-AKI (26.4 µmol/l increase over baseline) and Structural-AKI (140 ng/ml). If the diagnosis of Structural-AKI and Functional-AKI were to be made at only one time point then the patient would be initially negative for both classifications before becoming positive for Structural-AKI for a short period whilst remaining negative for Functional-AKI. From 2 to 16 hours the patients is positive for both Structural and Functional-AKI before becoming negative again for Structural-AKI.