Table 2. Malignancy incidence in secondary recipient mice in Exp. 1 (donor: γC −/−, recipient: γC −/− Rag2−/− ).
Vector | # Primary donor mice for secondary transplant | # Secondary recipients | # Vector+ Hematological Malignancies | # Other death* | # tumor free at autopsy(6–7 months) |
Mock | 11 | 23 | 0 | 1 | 22 |
MSCV | 14 | 36 | 0 | 13 | 23 |
EF1α | 15 | 39 | 3 ** | 3 | 33 |
Other death: Mice died or sacrificed before reaching end points, but not due to hematological malignancies that have transgene insertion (for examples, recipient derived tumor).
All three mice are from the same donor.
VCN: Vector copy number in peripheral blood mononuclear cells at 30 weeks.