Table 4. Malignancy incidence in secondary recipient mice in Exp 2 (Donor: CD45.1+; Recipient: CD45.2+).
Vector | # Primary donormice for secondarytransplant | # Secondary recipients | # Vector+HematologicalMalignancies | # Recipient derived hematological malignancies | # Other death* | # tumor free at autopsy(6–7 months) |
Mock | 14 | 42 | 0 | 3 | 2 | 37 |
MFG | 14 | 42 | 1** | 0 | 2 | 39 |
SFFV | 18 | 54 | 7 *** | 1 | 2 | 44 |
EF1α | 15 | 45 | 0 | 3 | 2 | 40 |
Other death: Mice died or sacrificed before reaching end points, but not due to hematological malignancies.
not definitive in terms of vector presence.
P<0.05.
VCN: Vector copy number in peripheral blood mononuclear cells at 30 weeks.