Table 5. Induction of proapoptotic molecules in lungs from pigs infected with Zaire ebolavirus.
Gene | Description | Fold change | ||
DPI 3 | DPI 5 | DPI 7 | ||
CASP1 | Caspase 1 | 2 | 13 | 12 |
CASP3 | Caspase 3 | 1 | 3 | 3 |
CASP1/4 | Caspase 1/3 | 2 | 6 | 5 |
CASP8 | Caspase 8 | 1 | 3 | 2 |
CASP15 | Caspase 15 | 1 | 3 | 5 |
CARD6 | Caspase recruitment domain family | 2 | 4 | 4 |
AATYK | Apoptosis-associated tyrosine kinase 2 | 1 | 4 | 4 |
FADD | Fas (TNFRSF6)-associated via death domain | 2 | 3 | 3 |
FAS | TNF receptor superfamily, member 6 | 2 | 5 | 5 |
TRAF3 | TNF receptor-associated factor 3 | 2 | 6 | 7 |
TNIP3 | TNFAIP3 interacting protein 3 isoform 3 | 3 | 10 | 14 |
AIF1 | Allograft inflammatory factor 1 | 1 | 3 | 3 |
Data was obtained by microarray analysis of RNA from lungs of pigs infected with Zaire ebolavirus in experiment 1. Numbers represent fold change in transcription relative to tissues from uninfected controls. DPI, days post infection. N = 2 pigs for controls, DPI 3, 5 and 7.