Figure 1. Adjuvant-induced mechanical hyperalgesia throughout the 21-day experimental period.

Each data point represents the mean ± SEM of the percentage decrease of the mechanonociceptive threshold of (A) Tac1^−/−, (B) Tac4^−/−, (C) Tacr1^−/−, (D) Tac1^−/−/Tac4^−/− mice compared to the initial control values (n = 9–24 mice per group; *p<0.05, **p<0.01, ***p<0.001 vs. C57Bl/6; two-way ANOVA followed by Bonferroni’s modified t-test).