Table 1. Clinicopathological findings and correlation with Cry1 expression.
| Variables | No. (%) | Cry1 low | Cry1 high | P value |
| Total cases | 168 | 67(39.9) | 101(60.1) | |
| Age (years) | ||||
| ≤65 | 127(75.6) | 47(37.0) | 80(63.0) | |
| >65 | 41(24.4) | 20(48.8) | 21(51.2) | 0.181 |
| Gender | ||||
| Male | 89 (53.0) | 39 (43.8) | 50 (56.2) | 0.268 |
| Female | 79 (47.0) | 28 (35.4) | 51 (64.6) | |
| Tumor location | ||||
| Colon | 85 (50.6) | 34 (40.0) | 51 (60.0) | 0.975 |
| Rectum | 83 (49.4) | 33 (39.8) | 50 (60.2) | |
| Tumor size(cm) † | ||||
| < = 5 | 92 (55.1) | 33 (35.9) | 59 (64.1) | 0.285 |
| >5 | 75 (44.9) | 33 (44.0) | 42 (56.0) | |
| Histology | ||||
| Adenocarcinoma | 146 (86.9) | 57 (39.0) | 89 (61.0) | 0.567 |
| Mucinous | 22 (13.1) | 10 (45.5) | 12 (54.5) | |
| Tumor invasive depth | ||||
| T1–T2 | 10 (6.0) | 6 (60.0) | 4 (40.0) | 0.180 |
| T3–T4 | 158 (94.0) | 61 (38.6) | 97 (61.4) | |
| Lymph node status | ||||
| N0 | 98(58.3) | 48(49.0) | 50(51.0) | * 0.004 |
| N1(n> = 1) | 70(41.7) | 19(27.1) | 51(72.9) | |
| Preoperative CEA(ng/mL) †† | ||||
| <5 | 98(65.8) | 38(38.8) | 60(61.2) | 0.330 |
| > = 5 | 51(34.2) | 24(47.1) | 27(52.9) | |
| AJCC/TNM stage | ||||
| I–II | 94(56.0) | 47 (50.0) | 47 (50.0) | * 0.003 |
| III–IV | 74 (44.0) | 20 (27.0) | 54 (73.0) | |
| Preoperative CA199(ng/mL) ††† | ||||
| < = 35 | 118 (80.3) | 51(43.2) | 67 (56.8) | 0.392 |
| >35 | 29 (19.7) | 10 (34.5) | 19 (65.5) |
*
Statistically significant. Numbers in parentheses indicate the proportion of tumors with a specific clinical or pathological feature in a given Cry1 subtype.
†
Analysis for this parameter was available for 167 cases.
††
Analysis for this parameter was available for 149 cases.
†††
Analysis for this parameter was available for 147cases.