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. 2013 Apr 23;8(4):e60369. doi: 10.1371/journal.pone.0060369

Figure 4. Down-regulation of miR-219-2-3p in gastric cancer cells is associated with methylation of miR-219-2-3p upstream region.

Figure 4

(A) A schematic illustration of deletion of a segment (90 M–141 M) of chromosome 9q34.11 where the miR-219-2-3p genes located. (B) Effect of 5-Aza-CdR and TSA on miR-219-2-3p expression in MGC-803 and HGC-27 gastric cancer cell lines. 5-Aza-CdR or 5-Aza-CdR combination with TSA significantly increased miR-219-2-3p levels. (C) Representative MSP results of miR-219-2-3p methylation in primary gastric cancer tumors and normal adjacent tumor tissues. Case numbers are shown on top. M: methylated primers; U: unmethylated primers. Cases with hypermethylation were marked.