Table 3. Age-adjusted RTL and anticipation in age at cancer diagnosis in parent-child pairs.
| PARENT | CHILD | |||||||||
| Family | MMR gene | Tumor | *Age | Sex | Age-adjusted RTL | Tumor | *Age | Sex | Age-adjusted RTL | **Telchild<Telparent |
| Cancer-affected carriers | ||||||||||
| Fam-1 | MSH2 | CRC | 73 | F | −0.172 | CRC | 45 | M | −0.216 | yes |
| Fam-2 | MSH2 | EC | 78 | F | 0.167 | CRC | 55 | F | −0.339 | yes |
| Fam-2 | MSH2 | CRC | 55 | F | −0.339 | CRC | 33 | F | −0.188 | no |
| Fam-2 | MSH2 | EC | 78 | F | 0.167 | CRC | 55 | F | −0.217 | yes |
| Fam-3 | MSH2 | CRC | 60 | F | −0.098 | CRC | 35 | F | 0.407 | no |
| Fam-4 | MLH1 | CRC | 53 | F | −0.143 | CRC | 40 (in surv) | F | 0.372 | no |
| Fam-4 | MLH1 | CRC | 53 | F | −0.143 | CRC | 32 | M | −0.521 | yes |
| Fam-5 | MLH1 | CRC | 48 | M | 0.328 | CRC | 35 | M | 0.567 | no |
| Fam-6 | MLH1 | CRC | 52 | F | 0.635 | CRC | 34 | F | 0.736 | no |
| Fam-7 | MLH1 | CRC | 50 | F | 0.388 | CRC | 55 (in surv) | F | −0.103 | yes |
| Fam-8 | MLH1 | CRC | 51 | M | −0.240 | CRC | 28 | F | −0.022 | no |
| Fam-9 | MLH1 | CRC | 51 | M | 0.332 | CRC | 45 | F | 0.178 | yes |
| Fam-10 | MLH1 | CRC | 33 | M | −0.398 | CRC | 24 | F | −0.154 | no |
| Fam-11 | MLH1 | CRC | 69 (in surv) | M | −0.298 | CRC | 37 | F | −0.206 | no |
| Fam-11 | MLH1 | CRC | 69 (in surv) | M | −0.298 | CRC | 41 (in surv) | F | −0.247 | no |
| Fam-12 | MLH1 | CRC | 66 | F | −0.014 | CRC | 47 | M | −0.373 | yes |
| Fam-12 | MLH1 | CRC | 66 | F | −0.014 | CRC | 39 | M | −0.322 | yes |
| Fam-12 | MLH1 | CRC | 66 | F | −0.014 | CRC | 40 | M | −0.103 | yes |
| Fam-13 | MLH1 | CRC | 60 | F | −0.081 | CRC | 38 | F | −0.030 | no |
| Fam-14 | MLH1 | CRC | 77 | F | −0.235 | CRC | 38 | F | −0.076 | no |
| Fam-15 | MSH6 | UC | 69 | M | −0.032 | CRC | 33 | M | −0.478 | yes |
| Cancer-free carriers | ||||||||||
| Fam-16 | MLH1 | - | 48 | M | −0.347 | - | 24 | M | −0.327 | no |
| Fam-16 | MLH1 | - | 48 | M | −0.347 | - | 25 | F | −0.688 | yes |
| Fam-17 | MLH1 | - | 47 | M | −0.121 | - | 27 | F | −0.387 | yes |
| Fam-18 | MLH1 | - | 64 | F | −0.244 | - | 36 | M | −0.095 | no |
| Fam-18 | MLH1 | - | 64 | F | −0.244 | - | 39 | M | −0.134 | no |
| Fam-19 | MLH1 | - | 45 | F | 0.048 | - | 18 | M | −0.202 | yes |
| Fam-20 | MLH1 | - | 78 | M | 0.399 | - | 37 | F | −0.186 | yes |
| Fam-21 | MSH2 | - | 47 | F | 0.552 | - | 22 | M | −0.021 | yes |
| Fam-22 | MSH6 | - | 65 | F | −0.230 | - | 30 | M | −0.300 | yes |
| *** Cancer-free non-carriers | ||||||||||
| Fam-23 | - | - | 71 | F | −0.336 | - | 45 | M | 0.000 | no |
| Fam-20 | - | - | 74 | F | −0.284 | - | 50 | M | −0.181 | no |
| Fam-24 | - | - | 85 | F | −0.268 | - | 53 | F | −0.432 | yes |
MMR: DNA mismatch repair; RTL: relative telomere length; CRC: colorectal cancer; EC: endometrial cancer; UC: urinary tract cancer; M: male; F: female; in surv: cancer diagnosed as a consequence of extensive clinical surveillance of LS families.
Age: Age at cancer diagnosis for cancer-afected carriers, and age at blood draw for cancer-free carriers and non-carriers
Telchild<Telparent, age-adjusted telomere length is shorter in the child than in the parent. “Yes” indicates that age-adjusted RTL is smaller in the child than in the parent, therefore indicating association with anticipation when cancer-affected carriers are studied.
Cancer-free non-carriers are individuals who belong to Lynch syndrome families but do not carry the pathogenic MMR gene mutation.