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. 2013 Apr 23;8(4):e61165. doi: 10.1371/journal.pone.0061165

Figure 2. Tamoxifen blocks the TGF-β1-induced MMT but does not revert the mesenchymal morphology of effluent-derived MCs.

Figure 2

(a to f) Omentum-derived MCs were treated or not for 48 hours with TGF-β1 in the presence of different doses of Tamoxifen (0, 3 and 6 µM). Phase-contrast microscopy shows that Tamoxifen treatment prevents the morphological change induced by TGF-β1. (g and h) Effluent-derived MCs with non-epithelioid morphology were either left untreated or treated with Tamoxifen (10 µM) during 48 hours. Phase-contrast microscopy shows that Tamoxifen does not revert the morphology of MCs to an epithelioid phenotype.