Figure 4.

Gene expression differences between adrenals from control and Sf1-Cre/Dicer^lox/lox embryos at E15.5 and E16.5. Heatmaps generated from Affymetrix gene expression arrays illustrate differentially expressed genes in adrenals from Dicer-KO and control (WT, cre⁻ littermates) embryos at E15.5 (A) and E16.5 (B). Data were filtered by excluding probe sets with an FDR of ≥.05 and a log₂-fold change of ≤1.5 or ≥−1.5. Yellow bars indicate an increase over the mean chip intensity, and blue indicates a decrease over mean intensity. FC represents log₂-fold change between the 4 Dicer-KO litters/replicates compared with the 4 WT litters/replicates.