Figure 6.

Differentially expressed miRNAs in adrenals from Sf1-Cre/Dicer^lox/lox embryos. Heatmaps were generated from OpenArray rodent miRNA analysis as described in Materials and Methods. A, Differentially expressed miRNAs at both E15.5 and E16.5 in Dicer-KO adrenals relative to control (WT, cre⁻ littermates) adrenals were filtered to select only those whose expression was changed significantly with a P value ≤ .05. Only miRNAs with a log₂-fold change of ≥1.5 or ≤−1.5 were included. FC represents log₂-fold change between the 4 Dicer-KO litters/replicates/samples compared with the 4 WT samples.