Table 2.
DAVID Enrichment Analysis Illustrating Differentially Expressed Genes Enriched for Specific GO Terms in Adrenals From E16.5 Dicer-KO Compared With Control (Top) and in Adrenals From E16.5 Compared With E15.5 Dicer-KO (Bottom)a
| Gene Ontology Gene List | Fold Enrichment | P Value |
|---|---|---|
| Enrichment in GO terms in differentially expressed genes in adrenals from E16.5 embryos | ||
| Innate immune response | 5.22 | 9.72 × 10−7 |
| Positive regulation of immune response | 5.20 | 2.27 × 10−8 |
| Activation of immune response | 5.19 | 1.78 × 10−5 |
| Immune effector process | 4.73 | 1.36 × 10−6 |
| Positive regulation of immune system process | 4.34 | 7.13 × 10−9 |
| Regulation of cytokine production | 4.29 | 4.71 × 10−6 |
| Positive regulation of response to stimulus | 4.00 | 6.00 × 10−7 |
| Regulation of cell activation | 3.82 | 1.92 × 10−5 |
| Cell activation | 3.78 | 4.72 × 10−8 |
| Leukocyte activation | 3.40 | 6.92 × 10−6 |
| Immune response | 3.32 | 2.48 × 10−11 |
| Response to wounding | 3.11 | 2.07 × 10−7 |
| Cell surface | 2.83 | 8.55 × 10−6 |
| Enrichment in GO terms in differentially expressed genes in adrenals from E16.5 compared with E15.5 embryos | ||
| Adaptive immune response | 12.58 | 1.80 × 10−5 |
| Inflammatory response | 8.05 | 2.36 × 10−7 |
| Response to wounding | 6.53 | 5.22 × 10−8 |
| External side of plasma membrane | 6.19 | 3.07 × 10−5 |
| Cell surface | 5.86 | 6.22 × 10−7 |
| Immune response | 5.45 | 5.78 × 10−8 |
| Carbohydrate binding | 5.36 | 3.33 × 10−5 |
| Defense response | 5.06 | 1.17 × 10−6 |
a
Data are filtered for FDR ≤0.05 and fold changes ≥1.5.