Table 2.
Pooled Measures on the Relations of MTHFR Gene C677T Polymorphisms to Hemorrhagic Stroke Risk
| |
|
Before HETRED analysis |
After HETRED analysis |
|||
|---|---|---|---|---|---|---|
| Data | Inherited model | FEM pooled OR (95% CI) | REM pooled OR (95% CI) | I2(%) | Pooled OR (95% CI) | I2(%) |
| All relevant articles | Dominant | 1.321 (1.165–1.499)b | 1.425 (1.149–1.767)b | 56 | 1.274 (1.120–1.449)a | 42.7 |
| Recessive | 1.416 (1.230–1.631)a | 1.583 (1.296–1.933)a | 33.5 | — | — | |
| Codominant | 1.280 (1.176–1.394)b | 1.395 (1.194–1.630)b | 61 | 1.279 (1.170–1.398)b | 42.1 | |
| Excluded for DHWE | Dominant | 1.418 (1.196–1.682)a | 1.551 (1.147–2.097)a | 63.9 | 1.611 (1.336–1.942)b | 45 |
| Recessive | 1.695 (1.409–2.038)b | 1.695 (1.409–2.040)b | 0.3 | — | — | |
| Codominant | 1.419 (1.265–1.591)b | 1.488 (1.225–1.808)b | 61.1 | 1.500 (1.330–1.692)b | 45.9 | |
a
p<0.05, bp<0.01.
CI, confidence interval; dominant model, TT+CT versus CC; recessive model, TT versus CT+CC; codominant model, T versus C; DHWE, deviated from HWE in controls; FEM, fixed effect model; REM, random effect model; HETRED, sensitivity analysis for reducing heterogeneity by omitting study using the STATA module of HETRED when I2>50%.