Table 1.
Summary of Clinical and Molecular Data of Several Members in the Pedigree with Diabetes Mellitus
| Subjects | Gender | Age at test (years) | Age at onset (years) | Degree of hearing loss | Audiogram shape | Diabetes mellitus | Associated illnesses | Heteroplasmy of A3243G (%) |
|---|---|---|---|---|---|---|---|---|
| 386101 | F | - | No | Normal hearing | No | No | No | 0 |
| 386102 | F | 55 | Unknown | Severe | Flat | No | Malignant brain tumor | 5.51 |
| 386104 | F | 46 | 40+ | Moderate to severe | Gently sloping | Yes | No | 14.33 |
| 386105 | F | 46 | 35+ | Severe | Gently sloping | Yes | No | 10.70 |
| 386201 | M | 29 | Unknown | Moderate to severe | Gently sloping | Yes | MELAS; stroke | 27.74 |
| 386202 | F | 31 | Unknown | Mild | High frequency | Yes | Liver transplant secondary to Crohn's disease | 25.89 |
| 386204 | F | 19 | Normal hearing | |||||
| 386205 | M | 15 | Normal hearing | |||||
| 386206 | M | 14 | Normal hearing |
MELAS, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.