Table 2.

Comparison of Assays Based on Serum or Plasma microRNAs for Diagnosing Lung Cancer

Diagnostic index	Summary	Serum microRNAs	Plasma microRNAs
Sensitivity	0.85	0.87	0.79
	(95% CI: 0.83–0.87)	(95% CI: 0.85–0.90)	(95% CI: 0.74–0.84)
Specificity	0.84	0.82	0.85
	(95% CI: 0.81–0.86)	(95% CI: 0.79–0.85)	(95% CI: 0.80–0.90)
PLR	5.23	4.82	4.84
	(95% CI: 3.75–7.29)	(95% CI: 3.02–7.68)	(95% CI: 2.96–7.90)
NLR	0.20	0.18	0.25
	(95% CI: 0.14–0.27)	(95% CI: 0.10–0.31)	(95% CI: 0.19–0.33)
DOR	31.77	32.74	19.84
	(95% CI: 16.98–59.42)	(95% CI: 12.04–89.00)	(95% CI: 9.70–40.61)
Q value	0.85	0.84	0.77
AUC	0.92	0.91	0.83

CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve.