Table 2.

Age, Sex, and Asymmetry Results for Fractional Anisotropy, Axial Diffusivity, and Radial Diffusivity for Hemispheres and Lobar Regions of Interest

		Age effects
	DTI metric	Linear		Quadratic		Cubic		Sex effects		Asymmetry effects
Region	FA mean	F	p	F	p	F	p	F	p	t	p
L Hemis	0.371±0.010	25.60	0.001	13.15	0.001	9.34	0.001	0.57	ns	20.53	0.001
R Hemis	0.356±0.009	26.19	0.001	14.61	0.001	9.61	0.001	0.13	ns	—	—
L Frontal	0.381±0.012	29.23	0.001	14.74	0.001	10.17	0.001	0.27	ns	14.63	0.001
R Frontal	0.366±0.010	18.05	0.001	9.15	0.001	6.03	0.001	0.16	ns	—	—
L Temporal	0.363±0.012	17.87	0.001	9.09	0.001	6.98	0.001	4.71	0.03	15.85	0.001
R Temporal	0.343±0.012	15.11	0.001	9.47	0.001	6.27	0.001	0.12	ns	—	—
L Parietal	0.357±0.011	9.51	0.003	5.10	0.009	4.51	0.006	0.54	ns	14.87	0.001
R Parietal	0.339±0.009	9.90	0.003	7.78	0.001	5.31	0.003	0.55	ns	—	—
L Occipital	0.336±0.013	8.24	0.006	4.06	0.022	2.73	0.05	0.02	ns	4.44	0.001
R Occipital	0.328±0.012	22.28	0.001	12.49	0.001	8.19	0.001	0.00	ns	—	—
L Callosum	0.585±0.029	14.22	0.001	7.01	0.001	4.60	0.001	4.22	ns	—	—
R Callosum	0.568±0.027	8.69	0.001	4.28	0.001	2.81	0.001	2.45	ns	—	—

	Axial mean	F	p	F	p	F	p	F	p	t	p
L Hemis	1.08±0.04	41.41	0.001	29.20	0.001	19.17	0.001	1.00	ns	−6.37	0.001
R Hemis	1.09±0.03	45.78	0.001	24.36	0.001	16.74	0.001	0.58	ns	—	—
L Frontal	1.08±0.04	35.53	0.001	24.51	0.001	16.46	0.001	0.01	ns	−5.31	0.001
R Frontal	1.10±0.04	32.54	0.001	17.21	0.001	12.25	0.001	0.61	ns	—	—
L Temporal	1.05±0.03	17.16	0.001	24.88	0.001	16.43	0.001	0.19	ns	−6.97	0.001
R Temporal	1.07±0.03	18.15	0.001	12.19	0.001	8.03	0.001	0.00	ns	—	—
L Parietal	1.04±0.06	38.70	0.001	20.07	0.001	13.49	0.001	0.16	ns	−6.81	0.001
R Parietal	1.06±0.06	44.13	0.001	21.73	0.001	15.35	0.001	0.55	ns	—	—
L Occipital	1.03±0.05	21.46	0.001	17.36	0.001	11.88	0.001	0.66	ns	−2.08	0.042
R Occipital	1.04±0.04	33.12	0.001	18.08	0.001	11.87	0.001	0.54	ns	—	—
L Callosum	1.50±0.07	3.79	0.001	8.36	0.001	5.49	0.001	0.01	ns	—	—
R Callosum	1.43±0.06	0.80	0.001	1.89	0.001	1.58	0.001	0.44	ns	—	—

	Radial mean	F	p	F	p	F	p	F	p	t	p
L Hemis	0.70±0.04	58.18	0.001	35.06	0.001	23.09	0.001	0.22	ns	−10.90	0.001
R Hemis	0.73±0.03	59.83	0.001	31.65	0.001	21.35	0.001	0.13	ns	—	—
L Frontal	0.69±0.04	54.39	0.001	32.42	0.001	21.34	0.001	0.01	ns	−11.42	0.001
R Frontal	0.73±0.04	37.93	0.001	19.78	0.001	13.36	0.001	0.02	ns	—	—
L Temporal	0.66±0.03	30.38	0.001	26.04	0.001	18.04	0.001	3.03	ns	−12.92	0.001
R Temporal	0.71±0.03	35.70	0.001	21.97	0.001	14.47	0.001	0.00	ns	—	—
L Parietal	0.73±0.05	45.96	0.001	23.11	0.001	15.17	0.001	0.02	ns	−9.09	0.001
R Parietal	0.77±0.05	47.22	0.001	23.33	0.001	16.62	0.001	0.22	ns	—	—
L Occipital	0.73±0.05	27.20	0.001	16.25	0.001	11.40	0.001	0.60	ns	−3.76	0.001
R Occipital	0.74±0.04	45.83	0.001	26.06	0.001	17.10	0.001	0.15	ns	—	—
L Callosum	0.59±0.07	13.65	0.001	10.77	0.001	7.08	0.001	0.95	ns	—	—
R Callosum	0.59±0.06	10.17	0.002	6.25	0.003	4.11	0.01	2.48	ns	—	—

L, left; R, right; Hemis, hemisphere (AD/RD Mean units: 10⁻³ mm²/s); FA, fractional anisotropy; RD, radial diffusivity; AD, axial diffusivity; DTI, diffusion tensor imaging.