FIG. 5.

Sedation-induced reorganization of hubs. (a) Spatial distribution of the top 10 hubs and their significant functional connections during the awake state. (b) Spatial distribution of the top 10 hubs and their significant functional connections during the sedation state. For (a) and (b), the hubs are represented by large red dots, whose sizes are proportional to their specific betweenness centrality values. The associated significant connections are represented by green lines, whose thicknesses also correspond to their specific connection values. Small yellow dots represent nonhub regions. All the regions (hubs and nonhubs) as well as the connections are overlaid on a translucent brain volume to show their relative locations. (c) The number of significant positive connections associated with the top 10 hubs in each condition. (d) Comparison of the strength of significant positive connections associated with the top 10 hubs between the two conditions. Error bars denote standard error of the mean.