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. 2013 Apr 9;136(5):1383–1398. doi: 10.1093/brain/awt062

Figure 5.

Figure 5

Association between clinical status and specific amyloid-β oligomers in the brain. (A) Amyloid-β dimer levels in Tris-buffered saline (TBS) extracts overlapped between groups but were significantly higher in subjects with probable Alzheimer’s disease (AD) than in subjects with mild cognitive impairment (MCI) or no cognitive impairment (N). (B) Amyloid-β trimer levels in extracellular (EC)-enriched fractions were highest in the group with mild cognitive impairment. (C and D) Aβ*56 levels in both in extracellular (EC)-enriched and membrane (MB)-enriched fractions were highest in subjects with no cognitive impairment. Group sizes are shown in parentheses. *P < 0.01; Kruskal-Wallis test followed by Mann-Whitney U test with Bonferroni corrections. Green symbols indicate no cognitive impairment, orange symbols mild cognitive impairment, red symbols probable Alzheimer’s disease, and blue symbols non-Alzheimer dementia. DLU = densitometry light units.