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. 2013 Mar 22;136(5):1399–1414. doi: 10.1093/brain/awt065

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© The Author (2013). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Voxel-based morphometry results showing (top left) areas of grey matter reduction in presymptomatic mutation carriers compared with control subjects after correction for multiple comparisons at FWE < 0.1 and the effect-map for the PMC versus control group comparison. In the effect-map, regions showing reduced grey matter in the PMC group are shown in red and in control subjects in blue. Differences between the two adjusted group-means are overlaid on a mean study-specific template. Images shown in radiological convention (right on left).