Table 1.
Baseline Demographic, Lifestyle, and Comorbidity Characteristics of Participants of the European Prospective Investigation of Cancer–Norfolk Cohort Cytomegalovirus (CMV) Study (N = 12 999), Grouped by CMV Antibody Status
| Characteristic | Negative for CMV Antibodies (n = 5366) | Positive for CMV IgG Antibodies |
P Valueb | |||
|---|---|---|---|---|---|---|
| Low Antibody Group (n = 2545) | Middle Antibody Group (n = 2544) | High Antibody Group (n = 2544) | P Valuea | |||
| Age at study entry, y, mean (SD) | 56.9 (9) | 59.0 (9) | 59.6 (9) | 61.1 (9) | <.001 | <.001 |
| Female sex | 53% | 50% | 56% | 62% | <.001 | <.001 |
| Education, A levelc and above | 58% | 52% | 52% | 46% | .26 | <.001 |
| Social class, nonmanual employment | 63% | 58% | 60% | 58% | .97 | <.001 |
| Townsend deprivation index, median (IQR) | −2.7 (−3.7 to −1.3) | −2.6 (−3.6 to −1.0) | −2.6 (−3.7 to −1.0) | −2.5 (−3.7 to −0.9) | .61 | <.001 |
| Ever smokers | 50% | 56% | 55% | 56% | .11 | <.001 |
| Alcohol consumption, units/wk, median (IQR) | 4.0 (1–10) | 4.0 (1–10) | 3.5 (1.9) | 2.5 (1–8) | .08 | .14 |
| Physical activity, moderately or very active | 44% | 41% | 41% | 37% | .73 | .25 |
| With prevalent diabetes mellitus | 2.5% | 3.4% | 3.3% | 3.9% | .58 | .04 |
| With prevalent myocardial infarction | 2.6% | 3.4% | 3.7% | 4.2% | .10 | .03 |
| With prevalent stroke | 1.2% | 1.3% | 1.6% | 1.8% | .42 | .87 |
| With prevalent cancer, excluding nonmelanoma skin cancer | 4.7% | 4.6% | 5.6% | 5.8% | .35 | .95 |
Abbreviations: CMV, cytomegalovirus; IgG, immunoglobulin G; IQR, interquartile range; SD, standard deviation.
a Age- and sex-adjusted P value for trend among thirds of antibody within participants with positive IgG antibodies.
b Age- and sex-adjusted P value comparing participants with positive IgG antibodies to participants with negative IgG antibodies.
c “A levels” corresponds to 12 years of school education in the United Kingdom.