Table 2.
Baseline Anthropometric and Biochemical Characteristics of Participants of the European Prospective Investigation of Cancer–Norfolk Cohort Cytomegalovirus (CMV) Study (N = 12 999), Grouped by CMV Antibody Status
| Negative for CMV Antibodies (n = 5366) | Positive for CMV IgG Antibodies |
P Valueb | ||||
|---|---|---|---|---|---|---|
| Low Antibody Group (n = 2545) | Middle Antibody Group (n = 2544) | High Antibody Group (n = 2544) | P Valuea | |||
| CMV IgG antibody, IU/mL, median (IQR) | 0.2 (0.2–0.2) | 3.0 (1.9–4.1) | 6.9 (5.7–8.4) | 14.1 (10.7–20.8) | <.001 | <.001 |
| Body mass index, kg/m2, mean (SD) | 26.1 (3.7) | 26.4 (3.7) | 26.3 (3.9) | 26.5 (4.1) | .45 | <.001 |
| Waist-to-hip ratio, mean (SD) | 0.85 (0.1) | 0.86 (0.1) | 0.86 (0.1) | 0.86 (0.1) | .29 | .02 |
| C-reactive protein, mg/L, mean (SD) | 2.9 (5.9) | 3.0 (5.6) | 3.3 (6.5) | 3.5 (7.6) | .05 | .07 |
| Ferritin, pmol/L, mean (SD) | 206.5 (172) | 206.4 (170) | 204.6 (172) | 194.1 (161) | .74 | .14 |
| Fibrinogen, µmol/L, median (IQR) | 8.3 (7.1–9.8) | 8.5 (7.1–9.9) | 8.5 (7.1–9.9) | 8.8 (7.4–9.9) | .18 | .61 |
| Glucose, mmol/L, median (IQR) | 4.0 (3.5–4.7) | 4.0 (3.5–4.7) | 4.1 (3.5–4.8) | 4.1 (3.6–4.8) | .26 | .77 |
| Cholesterol, mmol/L, median (IQR) | 6.0 (5.3–6.8) | 6.1 (5.4–6.9) | 6.1 (5.4–6.9) | 6.1 (5.4–6.9) | .07 | .15 |
| LDL, mmol/L, median (IQR) | 3.8 (3.2–4.6) | 3.9 (3.3–4.6) | 3.8 (3.2–4.6) | 3.9 (3.3–4.6) | .13 | .63 |
| HDL, mmol/L, median (IQR) | 1.4 (1.1–1.7) | 1.4 (1.1–1.6) | 1.3 (1.1–1.6) | 1.4 (1.1–1.7) | .001 | <.001 |
| Triglycerides, mmol/L, median (IQR) | 1.5 (1.0–2.2) | 1.5 (1.1–2.2) | 1.6 (1.1–2.3) | 1.6 (1.1–2.3) | .64 | <.001 |
| Systolic blood pressure, mm Hg, mean (SD) | 134.2 (17) | 135.1 (18) | 135.9 (18) | 137.2 (19) | .05 | .59 |
| Diastolic blood pressure, mm Hg, mean (SD) | 82.1 (11) | 82.3 (11) | 82.5 (11) | 82.9 (11) | .09 | .89 |
To obtain cholesterol, LDL, and HDL in mg/dL, divide mmol/L by 0.0259. To obtain triglycerides in mg/dL, divide mmol/L by 0.0113. To obtain glucose in mg/dL, divide mmol/L by 0.0555. To obtain fibrinogen in mg/dL, divide µmol/L by 0.0294. To obtain ferritin in ng/mL, divide pmol/L by 2.247.
Abbreviations: CMV, cytomegalovirus; HDL, high-density lipoprotein; IgG, immunoglobulin G; IQR, interquartile range; LDL, low-density lipoprotein; SD, standard deviation.
a Age- and sex-adjusted P value for trend among thirds of antibody within participants with positive IgG antibodies.
b Age- and sex-adjusted P value comparing participants with positive IgG antibodies to participants with negative IgG antibodies.