Table 3.

Hazard Ratios for All-Cause Mortality

Model	Model Adjustments	No.	All With Positive CMV IgG Antibodies	Low Antibody Group	Middle Antibody Group	High Antibody Group
Model 1	Age, sex	12 999	1.16 (1.07–1.26)	1.09 (.98–1.22)	1.14 (1.02–1.27)	1.26 (1.13–1.39)
Model 2	Age, sex, Townsend, smoking, educational level, physical activity, social class	12 612	1.14 (1.04–1.24)	1.07 (.95–1.20)	1.12 (.99–1.25)	1.23 (1.10–1.37)
Model 3	Age, sex, Townsend, smoking, educational level, physical activity, social class, BMI, WHR, total cholesterol	12 425	1.15 (1.05–1.25)	1.08 (.96–1.21)	1.13 (1.01–1.27)	1.24 (1.11–1.38)
Model 4	Age, sex, Townsend, smoking, educational level, physical activity, social class, BMI, WHR, total cholesterol, CRP	11 840	1.13 (1.03–1.24)	1.06 (.94–1.19)	1.11 (.99–1.24)	1.23 (1.09–1.37)
Model 4 sensitivity analysis	Excluding deaths during first 2 y of follow-up	11 707	1.12 (1.02–1.23)	1.06 (.94–1.19)	1.08 (.96–1.22)	1.23 (1.09–1.38)
	Participants without baseline cancer, MI, or CVA	10 684	1.11 (1.00–1.23)	1.06 (.93–1.21)	1.08 (.95–1.23)	1.19 (1.06–1.36)

Data are presented as hazard ratio (95% confidence interval). Reference group is participants with negative IgG antibody for CMV, the European Prospective Investigation of Cancer–Norfolk cohort CMV study (N = 12 999). All models are adjusted for age at recruitment to the study, sex, Townsend deprivation index [32], smoking, educational level, physical activity, social class, body mass index, waist-to-hip ratio, total cholesterol, C-reactive protein (see table below).

Abbreviations: BMI, body mass index; CMV, cytomegalovirus; CRP, C-reactive protein; CVA, cerebrovascular accident; IgG, immunoglobulin G; MI, myocardial infarction; Townsend, Townsend deprivation index [32]; WHR, waist-to-hip ratio.