Table 3.

Effects of mirabegron on voided volume per micturition

Parameter	Nitti et al43		Khullar et al44		Van Kerrebroeck et al45
	Placebo	Mirabegron 50 mg	Placebo	Mirabegron 50 mg	Placebo	Mirabegron 25 mg	Mirabegron 50 mg
Volume voided (mL) per micturition
n	480	472	433	424	415	410	426
Baseline (mean)	156.7	161.1	157.5	156.3	164.0	165.2	159.3
Change from baseline (adjusted mean)†	12.3	24.2	7.0	18.2	8.3	12.8	20.7
Difference from placebo (adjusted mean)†	–	11.9	–	11.1	–	4.6	12.4
95% confidence interval	–	(6.3, 17.4)	–	(4.4, 17.9)	–	(−1.6, 10.8)	(6.3, 18.6)
P-value		<0.001#		0.001#		0.15	<0.001#

Notes:

^†least squares mean adjusted for baseline, gender, and geographical region;

^#statistically significantly superior compared to placebo at the 0.05 level with multiplicity adjustment. Data from Mirabegron prescribing information.48