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. 2013 Mar 13;33(11):4923–4934. doi: 10.1523/JNEUROSCI.4672-12.2013

Figure 5.

Figure 5.

Anti-Aβ antibody inhibits AD-like neuropathology in Tg2576 mice vaccinated with Lu AF20513. A–D, Significant inhibition of numbers of 6E10-immunoreactive cored and diffused (A, B) and ThS-positive cored amyloid-β plaques (C, D) was detected in the brains of 15- to 17-month-old vaccinated Tg2576 mice (n = 20) compared with control animals (n = 17) of the same age. Aβ pathology was analyzed through the whole hemibrains (A, C) and compared in cortical versus hippocampal brain regions (B, D). Photomicrographs show representative images of hemibrain regions of immunized and control mice stained with 6E10 or ThS at a 4× magnification. Scale bar, 200 μm in A, C, D, and 10×. Scale bar (in B), 100 μm (boxed brain areas are shown in detail using 10× magnification). E, As a result of Lu AF20513 vaccination (n = 20), significant reduction of insoluble total β-amyloid levels in brain homogenates was observed compared with control mice (n = 17). F, Significant inhibition of soluble Aβ40 and Aβ42 levels detected in brain homogenates of immune mice (n = 20) compared with control animals (n = 17). Error bars represent average ± SD. ***p < 0.001.