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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: J Hepatol. 2013 Jan 20;58(5):993–999. doi: 10.1016/j.jhep.2013.01.011

Figure 2. Autophagy helps to control hepatic steatosis and liver injury under chronic ethanol condition.

Figure 2

(A–B) GFP-LC3 mice were given control diet (CD) or 29% ethanol diet (ED) for 4 weeks, followed by CQ administrated 16 hr before sacrifice. (C) Wild type mice were fed with CD or 36% ED for 4 weeks. A subgroup of mice was given CQ before sacrifice. The levels of LC3-II quantified by densitometry (normalized to the loading level and to the CD without CQ) were shown below the blot. (D-–E). Wild type mice were treated with CD or 29% ED for 4 weeks and given CQ 16 hr before sacrifice. Liver cryosections were stained with Bodipy (D) and the number of LDs were quantified (E). (F–H). Mice were treated as indicated and analyzed for hepatic TG (F), blood TG (G) and blood ALT (H) levels. #: p<0.05, *: p<0.01 (n=3–5 for A–E, 2–10 for F–H).