Figure 4. Enhanced autophagy alleviated HFD-induced steatosis.
Wild type mice were fed on a regular chew diet or a HFD for 12 weeks. CBZ or Rapamycin was injected every other day for two or three times, respectively, in the week before sacrifice. (A–B) Cryosections of the livers were stained with Bodipy 493/503 and the numbers of LDs were quantified. Hepatic (C) and blood (D) TG and blood ALT levels (E) were determined. (F–G) Blood glucose and insulin levels were measured in mice fed with HFD with or without rapamycin or CBZ treatment (F), from which the HOMA values were calculated (G). #: p<0.05, *: p<0.01(n=3–7).