Figure 3.

GCC and its downstream targets. (A) The domain structure of GCC. (B) Key proximal effectors activated by GCC in intestinal epithelial cells upon catalytic conversion of GTP to cGMP.

Abbreviations: cAMP, cyclic adenosine monophosphate; CaR, calcium-sensing receptor; CFTR, cystic fibrosis transmembrane conductance regulator; cGMP, cyclic guanosine monophosphate; CNG, cyclic nucleotide gated channel; GCC, guanylyl cyclase C; GTP, guanosine-5′-triphosphate; PDE, phosphodiesterases; PKA, protein kinase A; PKG, protein kinase G; VASP, vasodilator-stimulated phosphoprotein.