Table 1.
Characteristics of commonly used human prostate cancer cell lines. Characteristics, including androgen receptor (AR) level, p53 and phosphatase and tensin homolog (PTEN) status, androgen-dependency, and capability to generate prostate-specific antigen (PSA), of LNCaP 104-S, PC-3, and DU-145 cells are listed.
| LNCaP 104-S | PC-3 | DU-145 | |
|---|---|---|---|
| AR | + | − | − |
| p53 | + | − | mutant |
| PTEN | − | − | + |
| androgen-dependency | dependent | independent | independent |
| androgen effect on cell proliferation | stimulation | no response | no response |
| differentiation | well | poorly | poorly |
| originality | lymph-node metastases | bone-metastases | brain-metastases |
| PSA production | + | − | − |
| EC50 to CAPE treatment (μM) | 0.68 | 18.65 | 9.54 |